- El Fakih, Riad;
- Fox, Patricia;
- Popat, Uday;
- Nieto, Yago;
- Parmar, Simrit;
- Oran, Betul;
- Ciurea, Stephan;
- Kebriaei, Partow;
- Hosing, Chitra;
- Ahmed, Sairah;
- Shah, Jatin;
- Orlowski, Robert;
- Champlin, Richard;
- Qazilbash, Muzaffar;
- Bashir, Qaiser;
- Shah, Nina
BACKGROUND: We retrospectively analyzed our transplant database from July 2000 to June 2012 to identify myeloma patients who received autologous stem cell transplantation while dialysis-dependent. PATIENTS: 2091 patients underwent autologous high-dose therapy during this period. Twenty-four patients were dialysis-dependent. RESULTS: The 100-day and the 6, and 12-month treatment-related mortality was 0%. Overall response rate was 92%. The median progression-free survival and overall survival were 1.9 years and 3.8 years, respectively. A multivariate analysis was not performed because of the small sample size. Only 3 patients became dialysis-independent after transplantation. Cardiac, gastrointestinal, genitourinary, infectious, neurologic, and pulmonary all grade toxicities were all higher in the melphalan 200 group versus < 200 group, however, none of them were statistically significant. CONCLUSION: Because of a lack of clear survival benefit with higher-dose melphalan and potential higher toxicity in this group, it is reasonable to use lower-dose melphalan in dialysis-dependent myeloma patients.