- Liu, Ren;
- Lee, Jihwan;
- Tchoe, Youngbin;
- Pre, Deborah;
- Bourhis, Andrew M;
- D'Antonio‐Chronowska, Agnieszka;
- Robin, Gaelle;
- Lee, Sang Heon;
- Ro, Yun Goo;
- Vatsyayan, Ritwik;
- Tonsfeldt, Karen J;
- Hossain, Lorraine A;
- Phipps, M Lisa;
- Yoo, Jinkyoung;
- Nogan, John;
- Martinez, Jennifer S;
- Frazer, Kelly A;
- Bang, Anne G;
- Dayeh, Shadi A
We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms.