- Main
Integrated Molecular Characterization of Testicular Germ Cell Tumors
- Shen, Hui;
- Shih, Juliann;
- Hollern, Daniel P;
- Wang, Linghua;
- Bowlby, Reanne;
- Tickoo, Satish K;
- Thorsson, Vésteinn;
- Mungall, Andrew J;
- Newton, Yulia;
- Hegde, Apurva M;
- Armenia, Joshua;
- Sánchez-Vega, Francisco;
- Pluta, John;
- Pyle, Louise C;
- Mehra, Rohit;
- Reuter, Victor E;
- Godoy, Guilherme;
- Jones, Jeffrey;
- Shelley, Carl S;
- Feldman, Darren R;
- Vidal, Daniel O;
- Lessel, Davor;
- Kulis, Tomislav;
- Cárcano, Flavio M;
- Leraas, Kristen M;
- Lichtenberg, Tara M;
- Brooks, Denise;
- Cherniack, Andrew D;
- Cho, Juok;
- Heiman, David I;
- Kasaian, Katayoon;
- Liu, Minwei;
- Noble, Michael S;
- Xi, Liu;
- Zhang, Hailei;
- Zhou, Wanding;
- ZenKlusen, Jean C;
- Hutter, Carolyn M;
- Felau, Ina;
- Zhang, Jiashan;
- Schultz, Nikolaus;
- Getz, Gad;
- Meyerson, Matthew;
- Stuart, Joshua M;
- Akbani, Rehan;
- Wheeler, David;
- Laird, Peter W;
- Nathanson, Katherine L;
- Cortessis, Victoria K;
- Hoadley, Katherine A;
- Wang, Linghua;
- Xi, Liu;
- Wheeler, David A;
- Hughes, Daniel;
- Covington, Kyle;
- Jayaseelan, Joy C;
- Korchina, Viktoriya;
- Lewis, Lora;
- Hu, Jianhong;
- Doddapaneni, HarshaVardhan;
- Muzny, Donna;
- Gibbs, Richard;
- Hoadley, Katherine A;
- Hollern, Daniel;
- Vincent, Benjamin G;
- Chai, Shengjie;
- Smith, Christof C;
- Auman, J Todd;
- Shi, Yan;
- Meng, Shaowu;
- Skelly, Tara;
- Tan, Donghui;
- Veluvolu, Umadevi;
- Mieczkowski, Piotr A;
- Jones, Corbin D;
- Wilkerson, Matthew D;
- Balu, Saianand;
- Bodenheimer, Tom;
- Hoyle, Alan P;
- Jefferys, Stuart R;
- Mose, Lisle E;
- Simons, Janae V;
- Soloway, Matthew G;
- Roach, Jeffrey;
- Parker, Joel S;
- Hayes, D Neil;
- Perou, Charles M;
- Shih, Juliann;
- Cherniack, Andrew D;
- Meyerson, Matthew;
- Saksena, Gordon;
- Cibulskis, Carrie;
- Schumacher, Steven E;
- Beroukhim, Rameen;
- Gabriel, Stacey B;
- Bowlby, Reanne;
- Mungall, Andrew J;
- Brooks, Denise;
- Kasaian, Katayoon;
- Ally, Adrian;
- Balasundaram, Miruna;
- Carlsen, Rebecca;
- Cheung, Dorothy;
- Chuah, Eric;
- Dhalla, Noreen;
- Holt, Robert A;
- Jones, Steven JM;
- Ma, Yussanne;
- Mayo, Michael;
- Moore, Richard A;
- Robertson, A Gordon;
- Schein, Jacqueline E;
- Sipahimalani, Payal;
- Tam, Angela;
- Thiessen, Nina;
- Wong, Tina;
- Marra, Marco A;
- Shen, Hui;
- Zhou, Wanding;
- Laird, Peter W;
- Weisenberger, Daniel J;
- Van Den Berg, David J;
- Lai, Phillip H;
- Berrios, Mario;
- Holbrook, Andrea;
- Bootwalla, Moiz S;
- Maglinte, Dennis T;
- Armenia, Joshua;
- Sánchez-Vega, Francisco;
- Schultz, Nikolaus;
- Chakravarty, Debyani;
- Gao, Jianjiong;
- Heins, Zachary;
- Kundra, Ritika;
- Ochoa, Angelica;
- Liu, Minwei;
- Sander, Chris;
- Ladanyi, Marc;
- Thorsson, Vesteinn;
- Radenbaugh, Amie J;
- Newton, Yulia;
- Stuart, Joshua M;
- Cho, Juok;
- Heiman, David I;
- Noble, Michael S;
- Zhang, Hailei;
- Getz, Gad;
- Gehlenborg, Nils;
- Saksena, Gordon;
- Voet, Doug;
- Lin, Pei;
- Frazer, Scott;
- Kim, Jaegil;
- Lawrence, Michael S;
- Meier, Sam;
- Defreitas, Timothy;
- Chin, Lynda;
- Hegde, Apurva M;
- Akbani, Rehan;
- Weinstein, John N;
- Liu, Wenbin;
- Mills, Gordon B;
- Lu, Yiling;
- Pyle, Louise C;
- Pluta, John;
- Nathanson, Katherine L;
- Tickoo, Satish K;
- Reuter, Victor E;
- Mehra, Rohit;
- Looijenga, Leendert;
- Bryce, Alan H;
- Cárcano, Flavio M;
- Carvalho, André L;
- Cortessis, Victoria K;
- Feldman, Darren;
- Godoy, Guilherme;
- Ittmann, Michael;
- Jones, Jeffrey;
- Kulis, Tomislav;
- Lerner, Seth;
- Lessel, Davor;
- Nathanson, Katherine L;
- Shelley, Carl S;
- Vidal, Daniel O;
- Leraas, Kristen M;
- Lichtenberg, Tara M;
- Bowen, Jay;
- Gastier-Foster, Julie M;
- Gerken, Mark;
- Helsel, Carmen;
- Ramirez, Nilsa C;
- Wise, Lisa;
- Zmuda, Erik;
- Cottingham, Sandra;
- Chesla, David;
- Saller, Charles;
- Tarvin, Katherine;
- Lopes, Luiz Fernando;
- Scapulatempo-Neto, Cristovam;
- Aredes, Natália DA;
- Oosterhuis, Wolter;
- Gillis, Ad;
- Stoop, Hans;
- Eijkenboom, Wil;
- Sandusky, George;
- Martin, Sue Ellen;
- Aron, Manju;
- Daneshmand, Siamak;
- Djaladat, Hooman;
- Quinn, David;
- Dorff, Tanya;
- Lennerz, Jochen K;
- Thorne, Leigh B;
- Gamulin, Marija;
- Kastelan, Zeljko;
- Hudolin, Tvrtko;
- Kubisch, Christian;
- Boice, Lori;
- Huang, Mei;
- Perou, Amy H;
- Rathmell, W Kimryn;
- Pihl, Todd;
- Wan, Yunhu;
- Sun, Qiang;
- Naresh, Rashi;
- Chudamani, Sudha;
- Liu, Jia;
- Lolla, Laxmi;
- Wu, Ye;
- Ferguson, Martin L;
- Zenklusen, Jean C;
- Felau, Ina;
- Zhang, Jiashan;
- Sheth, Margi;
- Demchok, John A;
- Yang, Liming;
- Wang, Zhining;
- Tarnuzzer, Roy;
- Hutter, Carolyn M;
- Sofia, Heidi J;
- Davidsen, Tanja M
- et al.
Published Web Location
https://doi.org/10.1016/j.celrep.2018.05.039Abstract
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number. We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-