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Using time‐weighted average change from baseline of SARS‐CoV‐2 viral load to assess impact of hydroxychloroquine as postexposure prophylaxis and early treatment for COVID‐19
- Kumbhakar, Raaka;
- Neradilek, Moni;
- Barnabas, Ruanne V;
- Stewart, Jenell;
- Karita, Helen C Stankiewicz;
- Landovitz, Raphael J;
- Kissinger, Patricia J;
- Jerome, Keith R;
- Paasche‐Orlow, Michael K;
- Bershteyn, Anna;
- Chu, Helen Y;
- Neuzil, Kathleen M;
- Greninger, Alexander L;
- Luk, Alfred;
- Wald, Anna;
- Brown, Elizabeth R;
- Johnston, Christine
- et al.
Published Web Location
https://doi.org/10.1002/jmv.28054Abstract
Two randomized controlled trials demonstrated no clinical benefit of hydroxychloroquine (HCQ) for either postexposure prophylaxis or early treatment of SARS-CoV-2 infection. Using data from these studies, we calculated the time-weighted average change from baseline SARS-CoV-2 viral load and demonstrated that HCQ did not affect viral clearance.
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